Surface Modifications of an Organic Polymer-Based Microwire Platform for Sustained Release of an Anti-Inflammatory Drug.
RatOthermalen = 10 adult male ratsLocal release from implanted intracortical microwiresAt implantation, with sustained release thereafter
Model: Intracortical microwire electrode implantation injury and the resulting foreign body response
Dexamethasone-loaded hydrogel-coated microwires achieved exponential long-lasting release in vitro and, in a preliminary in vivo study, produced a general decrease in fold-change expression of inflammatory-related genes compared with drug-free functionalised controls.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.