Corticotropin-releasing factor inhibits thermal injury.
RatBurnScaldMaleIntravenous and intradermalMicrogram doses intravenously; nanogram doses intradermally…
Model: Thermal paw injury by immersion of the anaesthetised rat paw in 48 degrees C or 58 degrees C water for 5 min
CRF reduced heat-induced protein extravasation and oedema after both intravenous and intradermal dosing, with the much lower intradermal ED50 indicating a local action in paw skin. Ovine CRF and dynorphin A(1-13) intravenously also inhibited the response to 58 degrees C water, whereas morphine, eth…
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