CRH on esophageal motility in healthy volunteers
Esophageal Motility Disorders
Enrolment: 14 · Results not recorded
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Hormone · Diagnostic agent
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Esophageal Motility Disorders
Enrolment: 14 · Results not recorded
Gastrointestinal Hypersensitivity
Enrolment: 15 · Results not recorded
Peritumoral Brain Edema · Primary Malignant and Metastatic Brain Tumors
Enrolment: 60 · Results not recorded
Pituitary Neoplasm
Enrolment: 30 · Results not recorded
Cocaine-Related Disorders · Cocaine Addiction
Enrolment: 17 · Results not recorded
Hypopituitarism
Enrolment: 30 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Thermal paw injury by immersion of the anaesthetised rat paw in 48 degrees C or 58 degrees C water for 5 min
CRF reduced heat-induced protein extravasation and oedema after both intravenous and intradermal dosing, with the much lower intradermal ED50 indicating a local action in paw skin. Ovine CRF and dynorphin A(1-13) intravenously also inhibited the response to 58 degrees C water, whereas morphine, eth…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.