Modulation of lens-induced uveitis by dimethyl sulfoxide.
RatOtherLewisIntraperitoneal injection
Model: Lens-induced uveitis produced by sensitisation with bovine lens protein followed by disruption of the lens capsule
Intraperitoneal DMSO reduced retinal vasculitis, haemorrhage and necrosis, and morphometry showed a significant reduction in choroidal thickness in treated animals, suggesting that hydroxyl radicals contribute to ocular tissue damage.
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