Botulin-A Toxin/Dimethyl Sulfoxide Bladder Instillations for Voiding Dysfunction in Women
Overactive Bladder · Detrusor Instability · Detrusor Hyperreflexia
Enrolment: 25 · Results not recorded
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Drug · Mechanism of action recorded in ChEMBL as 'Unknown'; approved intravesically for interstitial cystitis.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Overactive Bladder · Detrusor Instability · Detrusor Hyperreflexia
Enrolment: 25 · Results not recorded
Dimethyl Sulfoxide
Enrolment: 68 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Hind-paw incision wound model of acute pain
A single 10 microlitre intrawound dose of 100% DMSO persistently attenuated guarding behaviour over 3 days without affecting thermal hyperalgesia or allodynia, and wound healing was normal at the end of the study.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Lens-induced uveitis produced by sensitisation with bovine lens protein followed by disruption of the lens capsule
Intraperitoneal DMSO reduced retinal vasculitis, haemorrhage and necrosis, and morphometry showed a significant reduction in choroidal thickness in treated animals, suggesting that hydroxyl radicals contribute to ocular tissue damage.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute radiation-induced oral mucositis produced by high single-dose and fractionated irradiation of the head and neck area
DMSO pretreatment protected the oral mucosa from severe acute radiation injury, limited weight loss and preserved proliferative lingual epithelial stem and progenitor cells, with efficacy superior to keratinocyte growth factor and amifostine and no significant effect on tumour weight in xenograft m…
Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.
Model: Corrosive oesophageal burn of the distal oesophagus created with 1 N hydrochloric acid (acid burn) or 50 percent sodium hydroxide (alkali burn)
Dimethyl sulfoxide significantly reduced the severity of acute macroscopic and microscopic tissue damage in both acid and alkali corrosive oesophagitis, significantly suppressed the raised Ki-67 proliferation index in the alkali group and significantly reduced NF-kappaB immunoreactivity in both bur…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.