Therapeutic effects of bone marrow mesenchymal stem cells via modulation of TLR2 and TLR4 on renal ischemia-reperfusion injury in male Sprague-Dawley rats.
RatIschaemia-reperfusionRenalSprague-DawleyMalen = 30 rats in total, 10 per group across three groupsIntraperitoneal1.5 x 10 cells per rat as printed in the retrieved text; th…Immediately after termination of renal ischaemia, at the onset of reperfusion
Model: Bilateral renal pedicle clamping with a micro-aneurysm vascular clamp for 45 minutes of warm ischaemia followed by 24 hours of reperfusion
Cell treatment partially reversed injury, lowering blood urea nitrogen from 166.5 plus or minus 12.9 to 99 plus or minus 14.7 and creatinine from 3.7 plus or minus 0.22 to 1.79 plus or minus 0.14 relative to untreated ischaemia-reperfusion, with reduced tubular damage and vascular congestion, thoug…
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