THERAPY DOSSIER · th-79653f4f4414

Allogeneic rat bone marrow mesenchymal stromal cells (CD105 positive, CD90 positive, CD34 negative)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 9

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02448849 ↗Injury indicationPHASE2/PHASE3unknown

Autologous Bone Marrow Derived Mesenchymal Stromal Cells With Platelet Lysate for Long Bone Nonunion

Bone Fracture

Enrolment: 60 · Results not recorded

NCT02582775 ↗PHASE2completed

Biochemical Correction of Severe Epidermolysis Bullosa by Allogeneic Cell Transplantation and Donor Mesenchymal Cell Infusions

Epidermolysis Bullosa

Enrolment: 17 · Results not recorded

NCT04759105 ↗PHASE2completed

Autologous Mesenchymal Stem/Stromal Cells for Chronic Low Back Pain Due to Disc Degeneration

Intervertebral Disc Degeneration · Chronic Low-back Pain

Enrolment: 48 · Results not recorded

NCT05794425 ↗PHASE1/PHASE2unknown

Umbilical Cord Blood Combined With Umbilical Cord Derived Mesenchymal Stem Cells for Bone Marrow Failure

Bone Marrow Failure Disorders

Enrolment: 100 · Results not recorded

NCT01586312 ↗PHASE1/PHASE2completed

Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells (MSV)

Osteoarthritis, Knee · Knee Osteoarthritis

Enrolment: 30 · Results not recorded

NCT02323789 ↗PHASE1/PHASE2unknown

Allogeneic Mesenchymal Stromal Cells in Adults With Recessive Dystrophic Epidermolysis Bullosa

Recessive Dystrophic Epidermolysis Bullosa

Enrolment: 10 · Results not recorded

NCT02409940 ↗PHASE1unknown

Mesenchymal Stem Cells on Immune Modulation in Living Related Kidney Transplant Patients

Renal Transplant Rejection

Enrolment: 17 · Results not recorded

NCT03504241 ↗PHASE1completed

Donor-derived Mesenchymal Stromal Cells for Tolerance Induction in Adult Kidney Allograft Recipients

Kidney Transplantation · Renal Transplant Recipient

Enrolment: 8 · Results not recorded

NCT01686139 ↗PHASE1unknown

Treatment of Diabetic Foot Complications With Allogeneic Bone Marrow Derived Mesenchymal Stromal Cells

Type I Diabetes Mellitus With Ulcer · Type II Diabetes Mellitus With Ulcer

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 34336610 ↗2020Reported benefit

Therapeutic effects of bone marrow mesenchymal stem cells via modulation of TLR2 and TLR4 on renal ischemia-reperfusion injury in male Sprague-Dawley rats.

RatIschaemia-reperfusionRenalSprague-DawleyMalen = 30 rats in total, 10 per group across three groupsIntraperitoneal1.5 x 10 cells per rat as printed in the retrieved text; th…Immediately after termination of renal ischaemia, at the onset of reperfusion

Model: Bilateral renal pedicle clamping with a micro-aneurysm vascular clamp for 45 minutes of warm ischaemia followed by 24 hours of reperfusion

Cell treatment partially reversed injury, lowering blood urea nitrogen from 166.5 plus or minus 12.9 to 99 plus or minus 14.7 and creatinine from 3.7 plus or minus 0.22 to 1.79 plus or minus 0.14 relative to untreated ischaemia-reperfusion, with reduced tubular damage and vascular congestion, thoug…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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