Effect of Different-Volume Fluid Resuscitation on Organ Functions in Severe Acute Pancreatitis and Therapeutic Effect of.
RatChemical/toxinSprague-DawleyMalen = 30 rats in total, 6 per group across five groups; a separat…Saline given intravenously by tail vein microinjection pump; herbal agent given intraduodenally via an implanted catheterLow volume fluid resuscitation 1.5 mL/kg/h; high volume 10…Fluid resuscitation started 30 minutes after induction of pancreatitis; the her…
Model: Severe acute pancreatitis induced by retrograde biliopancreatic ductal infusion of 3.5% sodium taurocholate at 1 mL/kg delivered at 6 mL/h
High volume resuscitation improved pH, oxygenation, lactate and oliguria relative to low volume but increased ascites, blood urea nitrogen, creatinine and kidney pathology scores, and the herbal co-treatment reduced those renal indices and raised arterial oxygen saturation relative to high volume r…
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