THERAPY DOSSIER · th-a091713c60d3

Intravenous normal saline fluid resuscitation at low versus high volume, with an intraduodenal traditional Chinese herbal co-treatment

Procedure · Fluid resuscitation strategy plus crude herbal preparation; no ChEMBL drug entity applicable.

Evidence & regulatory context

Mechanism: Fluid resuscitation strategy plus crude herbal preparation; no ChEMBL drug entity applicable.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02782819 ↗NAunknown

Crystalloid alone versus crystalloid plus colloid in shock resuscitation

Hypotension and Shock

Enrolment: 320 · Results not recorded

NCT01449721 ↗NAcompleted

Preemptive empiric resuscitation protocol (intravenous fluid) for prevention of disease progression in sepsis

Sepsis · Severe Sepsis

Enrolment: 142 · Results not recorded

NCT01774214 ↗NAcompleted

Rapid pediatric fluid resuscitation: two provider-endorsed manual fluid resuscitation techniques

Resuscitation · Shock · Fluid Therapy

Enrolment: 16 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33628293 ↗2020Mixed findings

Effect of Different-Volume Fluid Resuscitation on Organ Functions in Severe Acute Pancreatitis and Therapeutic Effect of.

RatChemical/toxinSprague-DawleyMalen = 30 rats in total, 6 per group across five groups; a separat…Saline given intravenously by tail vein microinjection pump; herbal agent given intraduodenally via an implanted catheterLow volume fluid resuscitation 1.5 mL/kg/h; high volume 10…Fluid resuscitation started 30 minutes after induction of pancreatitis; the her…

Model: Severe acute pancreatitis induced by retrograde biliopancreatic ductal infusion of 3.5% sodium taurocholate at 1 mL/kg delivered at 6 mL/h

High volume resuscitation improved pH, oxygenation, lactate and oliguria relative to low volume but increased ascites, blood urea nitrogen, creatinine and kidney pathology scores, and the herbal co-treatment reduced those renal indices and raised arterial oxygen saturation relative to high volume r…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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