Controlled release of baricitinib from a thermos-responsive hydrogel system inhibits inflammation by suppressing JAK2/STAT3 pathway in acute spinal cord injury.
RatSpinal cord injuryUnspecifiedSprague-DawleyLocal injection of the hydrogel into the injured spinal cordInjected at the time of injury surgery
Model: Acute spinal cord injury in rats
The baricitinib hydrogel inhibited JAK2 and STAT3 phosphorylation, suppressed inflammatory cytokines and reduced neuronal apoptosis early after injury, and later promoted functional recovery.
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