THERAPY DOSSIER · th-26e9e697fdd4

Baricitinib delivered from an injectable PLGA-PEG-PLGA thermo-responsive hydrogel

Drug · JAK1/JAK2 inhibitor.

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Evidence & regulatory context

Mechanism: JAK1/JAK2 inhibitor.
Target: CHEMBL2835 (JAK1); CHEMBL2971 (JAK2)
Injury models: Spinal cord injury
Reported indication: Rheumatoid arthritis (2017/2018); also hospitalised COVID-19 and severe alopecia areata (JAK1/2 inhibitor; Olumiant)
First approval: 2017
Development stage: Approved for RA/COVID-19; intracerebral-haemorrhage hydrogel investigational
ChEMBL record: CHEMBL2105759 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Olumiant; INCB028050; LY3009104
Note: Not recorded

Clinical trials 4

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06737705 ↗Injury indicationPHASE2completed

Trial title not recorded

Intracerebral Hemorrhage

Enrolment: 110 · Results not recorded

NCT04390464 ↗PHASE4unknown

Trial title not recorded

COVID19

Enrolment: 1167 · Results not recorded

NCT05955066 ↗PHASE4recruiting

Trial title not recorded

Rheumatoid Arthritis

Enrolment: 60 · Results not recorded

NCT01490632 ↗PHASE2completed

Trial title not recorded

Psoriasis

Enrolment: 271 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33385822 ↗2020Reported benefit

Controlled release of baricitinib from a thermos-responsive hydrogel system inhibits inflammation by suppressing JAK2/STAT3 pathway in acute spinal cord injury.

RatSpinal cord injuryUnspecifiedSprague-DawleyLocal injection of the hydrogel into the injured spinal cordInjected at the time of injury surgery

Model: Acute spinal cord injury in rats

The baricitinib hydrogel inhibited JAK2 and STAT3 phosphorylation, suppressed inflammatory cytokines and reduced neuronal apoptosis early after injury, and later promoted functional recovery.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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