Coadministration of Ketamine and Perampanel Improves Behavioral Function and Reduces Inflammation in Acute Traumatic Brain Injury Mouse Model.
MouseTBIWeight-drop / impact-accelerationC57BL/6JMalen = 44 mice in total across five groups, 8 or 9 per group; bloo…Ketamine intraperitoneal; perampanel oralKetamine 40 mg/kg; perampanel 4 mg/kg30 minutes after injury
Model: Closed head weight-drop traumatic brain injury, a 30 g metallic mass dropped freely through a hollow tube from 80 cm onto the left anterior frontal area
Ketamine alone improved anxiety-related behaviour, spontaneous alternation, recognition memory and NF-kappa B and iNOS levels, while the ketamine and perampanel combination additionally restored exploratory distance travelled and normalised traumatic brain injury related plasma metabolite changes i…
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