Ketamine Infusion for Treatment of Chronic Neuropathic Pain in Traumatic Brachial Plexus Injuries, a Prospective Randomized Control Study
Brachial Plexus Injury
Enrolment: 100 · Results not recorded
Loading the evidence…
Drug · Glutamate [NMDA] receptor negative allosteric modulator (NEGATIVE ALLOSTERIC MODULATOR); direct interaction, disease efficacy true.
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Brachial Plexus Injury
Enrolment: 100 · Results not recorded
PTSD · Posttraumatic Stress Disorder
Enrolment: 163 · Results not recorded
Post-traumatic Stress Disorder
Enrolment: 12 · Results not recorded
Ketamine
Enrolment: 80 · Results not recorded
Post Operative Pain
Enrolment: 80 · Results not recorded
Obesity · Bariatrics · Sleep Apnea Syndromes · Gastric Bypass · Endoscopy
Enrolment: 22 · Results not recorded
Laminectomy
Enrolment: 13 · Results not recorded
Fetal or Neonatal Effect of Damage to Placenta From Caesarean Section
Enrolment: 600 · Results not recorded
Depression
Enrolment: 72 · Results not recorded
Old Age · Knee Replacement Surgery · Hip Replacement Surgery · Sleep Quality
Enrolment: 154 · Results not recorded
Chronic Low Back Pain
Enrolment: 56 · Results not recorded
Pain, Acute · Pain, Chronic · Pain, Neuropathic
Enrolment: 32 · Results not recorded
Neuralgia · Chronic Pain · Inflammation
Enrolment: 48 · Results not recorded
Treatment Resistant Depression · Major Depressive Disorder
Enrolment: 403 · Results not recorded
Complex Regional Pain Syndrome
Enrolment: 3 · Results not recorded
Post Partum Depression
Enrolment: 1 · Results not recorded
Opioid Use Disorder
Enrolment: 88 · Results not recorded
Depression · Mild Cognitive Impairment
Enrolment: 15 · Results not recorded
Depression
Enrolment: 202 · Results not recorded
Neuropathic Pain
Enrolment: 22 · Results not recorded
9 studies reported at therapy level; 9 evidence entries itemised.
Model: Alpha-naphthylthiourea (ANTU) induced acute lung injury, ANTU 10 mg/kg intraperitoneally
All agents significantly reduced pleural effusion formation at every dose. Ketamine significantly reduced inflammation, haemorrhage and oedema scores, while midazolam 2 mg/kg and ketamine/xylazine significantly reduced inflammation and oedema scores.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Closed head weight-drop traumatic brain injury, a 30 g metallic mass dropped freely through a hollow tube from 80 cm onto the left anterior frontal area
Ketamine alone improved anxiety-related behaviour, spontaneous alternation, recognition memory and NF-kappa B and iNOS levels, while the ketamine and perampanel combination additionally restored exploratory distance travelled and normalised traumatic brain injury related plasma metabolite changes i…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Neonatal asphyxia; two 10-min episodes of anoxia (100% N2) 24 h apart
Ketamine reversed elevated glutamate and nitric oxide but failed to reverse anoxia-induced mitochondrial dysfunction in the secondary phase.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Closed distal tibia fracture of the right hindlimb made with a haemostat followed by 3 weeks of hindlimb cast immobilisation, a model of complex regional pain syndrome
Ketamine infused 3 weeks after fracture did not alter limb temperature, oedema or mechanical thresholds, whereas infusion at 7 weeks produced anti-allodynia that persisted for 4 weeks after the infusion ended, reduced capsaicin-evoked behaviours at 18 weeks (mean difference -49.92, 95% CI -66.52 to…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Moderate acute spinal cord injury in rats
Ketamine-treated rats had significantly lower TNF-alpha, IL-6 and malondialdehyde levels and fewer TUNEL-positive cells than saline controls at each time point.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Middle cerebral artery occlusion model of ischaemic stroke
(R)-ketamine attenuated brain injury and behavioural abnormalities whether given after or before and after occlusion, whereas (S)-ketamine at the same dose had no effect.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Spared nerve injury (neuropathic pain); paw-withdrawal heat (acute pain)
Ketamine, norketamine and the NR2B-selective antagonist traxoprodil all produced antinociception and long-lasting relief of allodynia, with traxoprodil showing separation from side effects.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Acute thoracic spinal cord compression under isoflurane, with a microvascular clip placed vertically over the exposed cord for 60 s after laminectomy with dura intact; lumbar intrathecal catheter implanted 3 weeks later
Intrathecal muscimol and baclofen each produced dose-dependent antinociception with peak effects of 58.5 and 85.9 per cent maximum possible effect, whereas ketamine and [Ser1]histogranin were ineffective alone. Only baclofen plus ketamine was synergistic and this was fully blocked by CGP 35348 pret…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Dorsal laminectomy followed by spinal cord injury induced with a temporary aneurysm clip
All three drugs reduced lipid peroxidation in the acute stage, but only (S)-ketamine did so significantly in the subacute stage, making it more effective than racemic ketamine or methylprednisolone for this endpoint. Histopathological protection with (S)-ketamine was comparable to methylprednisolon…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.