Ethyl pyruvate improves white matter remodeling in rats after traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMalen = n = 10 per group for behaviour; n = 5 per group for histolo…Intraperitoneal30 mg/kgFirst dose 15 min after injury
Model: Unilateral controlled cortical impact, right parietal craniotomy 5.4 mm diameter, 5 mm impactor tip, 4.0 m/s velocity, 3.2 mm depth, 0.5 s dwell
Ethyl pyruvate improved sensorimotor performance to day 21, reduced myelin loss, increased Olig2 positive oligodendrocyte precursors, lowered the g-ratio at 28 days and shifted microglia toward the M2 phenotype with reduced pro-inflammatory gene expression.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.