The Effectiveness and Safety of Cleanser Containing Triethyl Citrate, Pyruvic Acid, Combination Cream and Spot Cream As Adjuvant Therapy for Mild to Moderate Acne Vulgaris
Acne Vulgaris
Enrolment: 102 · Results not recorded
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Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acne Vulgaris
Enrolment: 102 · Results not recorded
Coronary Disease · Heart Valve Diseases
Enrolment: 150 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Weight-drop parietal cortical contusion traumatic brain injury
Ethyl pyruvate reduced HMGB1/TLR4/NF-kB inflammation, brain oedema and apoptosis and improved beam walking after traumatic brain injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Unilateral controlled cortical impact, right parietal craniotomy 5.4 mm diameter, 5 mm impactor tip, 4.0 m/s velocity, 3.2 mm depth, 0.5 s dwell
Ethyl pyruvate improved sensorimotor performance to day 21, reduced myelin loss, increased Olig2 positive oligodendrocyte precursors, lowered the g-ratio at 28 days and shifted microglia toward the M2 phenotype with reduced pro-inflammatory gene expression.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Blunt thoracic trauma followed by haemorrhagic shock at 35 +/- 3 mmHg for 60 min and resuscitation; sham animals underwent surgical procedures only; analyses 2 h after resuscitation
Ethyl pyruvate significantly improved arterial oxygenation compared with Ringer's lactate alone after blunt thoracic trauma and haemorrhagic shock. It reduced lactate dehydrogenase and total protein in bronchoalveolar lavage fluid and lessened histological lung damage, lung TNF-alpha and polymorpho…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Radiation-induced lung injury from a single thoracic irradiation of 16 Gy X-rays
Ethyl pyruvate reduced pulmonary inflammatory infiltration and HMGB1, IL-6, IL-1beta and GM-CSF at 4 weeks, and lowered collagen deposition with reduced TGF-beta1 and HMGB1 at 20 weeks after irradiation.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Unilateral controlled cortical impact, 5 mm flat tip, 3.2 mm depth, 0.5 s dwell, 4.0 m/s velocity, via 5.4 mm right parietal craniotomy; sham craniotomy controls
Ethyl pyruvate 30 mg/kg improved sensorimotor and cognitive performance and reduced tissue loss to 28 days, and at 48 hours reduced blood-brain barrier permeability, oedema, MMP-9 activity, tight junction degradation and neuroinflammation.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.