Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species.
RatSpinal cord injuryContusionSprague-DawleyFemalen = n = 9 per group for the three treated groups; n for untreat…Intraspinal injection at the T10 lesion site2.5 ug or 10 ug per rat (10 ug from a 1 mg/mL solution for…After establishment of the contusion model; 30 min post-contusion for the apopt…
Model: Contusion (weight-drop) traumatic spinal cord injury: T10 laminectomy, 40 g rod of 2.5 mm diameter dropped from 40 mm onto the exposed dorsal cord
Se-CQDs produced a dose-dependent improvement in BBB score at 8 weeks (10 ug 12.40 plus or minus 0.45 and 2.5 ug 9.80 plus or minus 0.68 versus saline 6.80 plus or minus 0.37), with faster return of spontaneous urination, less demyelination, fewer CD68 positive cells, reduced glial scarring and red…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.