THERAPY DOSSIER · th-718da913be10

Selenium-doped carbon quantum dots (Se-CQDs)

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33363370 ↗2020Reported benefit

Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species.

RatSpinal cord injuryContusionSprague-DawleyFemalen = n = 9 per group for the three treated groups; n for untreat…Intraspinal injection at the T10 lesion site2.5 ug or 10 ug per rat (10 ug from a 1 mg/mL solution for…After establishment of the contusion model; 30 min post-contusion for the apopt…

Model: Contusion (weight-drop) traumatic spinal cord injury: T10 laminectomy, 40 g rod of 2.5 mm diameter dropped from 40 mm onto the exposed dorsal cord

Se-CQDs produced a dose-dependent improvement in BBB score at 8 weeks (10 ug 12.40 plus or minus 0.45 and 2.5 ug 9.80 plus or minus 0.68 versus saline 6.80 plus or minus 0.37), with faster return of spontaneous urination, less demyelination, fewer CD68 positive cells, reduced glial scarring and red…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

Loading the evidence…