Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney.
MouseIschaemia-reperfusionRenalC57BL/6JMalen = Four randomly selected animals per group for histology; thr…Intraperitoneal for the acute dose, oral (drinking water) for maintenance10 mg/kg intraperitoneally, then 1 mmol/kg/day in drinking…Single intraperitoneal dose 2 h before ischaemia (pre-treatment)
Model: Unilateral warm ischaemia of the left kidney by clamping for 45 min followed by 2 weeks of reperfusion; right kidney inspected but left intact
Nitrate given before ischaemia and continued for 2 weeks improved BUN and GFR, prevented the rise in blood pressure and renal angiotensin II, reduced tubular and glomerular damage, macrophage infiltration and apoptosis, and blunted angiotensin II-mediated vasoconstriction.
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