Effects of Sodium Nitrate on Blood Flow in Becker Muscular Dystrophy
Becker Muscular Dystrophy
Enrolment: 19 · Results not recorded
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Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Becker Muscular Dystrophy
Enrolment: 19 · Results not recorded
Heart Failure With Preserved Ejection Fraction
Enrolment: 53 · Results not recorded
Heart Failure
Enrolment: 84 · Results not recorded
Cardiovascular Diseases
Enrolment: 300 · Results not recorded
Heart Failure
Enrolment: 42 · Results not recorded
Endothelial Dysfunction
Enrolment: 20 · Results not recorded
Cardiovascular Diseases
Enrolment: 78 · Results not recorded
Vascular Dilation · Arterial Stiffness
Enrolment: 24 · Results not recorded
Blood Pressure · Endothelial Dysfunction
Enrolment: 67 · Results not recorded
Blood Pressure · Cardiovascular Risk Factor
Enrolment: 40 · Results not recorded
no Medications
Enrolment: 20 · Results not recorded
Muscle Protein Synthesis
Enrolment: 25 · Results not recorded
Non ST Segment Elevation Acute Coronary Syndrome · Contrast Induced Nephropathy
Enrolment: 130 · Results not recorded
Cardiovascular Diseases
Enrolment: 300 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Unilateral warm ischaemia of the left kidney by clamping for 45 min followed by 2 weeks of reperfusion; right kidney inspected but left intact
Nitrate given before ischaemia and continued for 2 weeks improved BUN and GFR, prevented the rise in blood pressure and renal angiotensin II, reduced tubular and glomerular damage, macrophage infiltration and apoptosis, and blunted angiotensin II-mediated vasoconstriction.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Unilateral renal ischaemia-reperfusion: left renal pedicle clamped with a micro serrefine (100 g clamping pressure) for 30 min, followed by 24 h or 2 weeks of reperfusion
Nitrate-supplemented chow reduced tubular and glomerular damage and preserved renal function after unilateral ischaemia-reperfusion, with plasma creatinine at 24 h falling from 1.03 to 0.79 ug/ml and glomerular filtration rate and renal plasma flow both improved at 2 weeks. Protection was accompani…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.