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PRECLINICAL PUBLICATION · 2020

Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 33356694 ↗2020Reported benefit

Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury.

RatSpinal cord injuryCompressionSprague-DawleyBoth, half male and half femalen = 80 rats in total, five groups of n = 16Non-invasive trans-spinal magnetic stimulation over the T6, T10 or L2 segment5 Hz, 75% maximum output intensity (1.5 T), 5 s per sequenc…Treatment started on postoperative day 4

Model: Acute aneurysm-clip compression spinal cord injury: T10 laminectomy, Yasargil titanium mini clip (closing force 70 g) applied at T10 for 10 s

rTSMS at all three segments raised BBB scores versus untreated injury, alleviated myelin damage, lowered Nogo-A, NgR and apoptotic proteins and increased GAP43, with L2 stimulation giving the greatest late motor gain, although the 5-HT immunohistochemistry and immunofluorescence results were intern…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.