Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma.
RatTBIFluid percussionInbred strain not specifiedMaleProphylactic treatment before injury
Model: Fluid percussion traumatic brain injury at graded severities
Fluid percussion injury caused a rapid and profound fall in brain intracellular free Mg2+ that correlated with injury severity, accompanied at high injury levels by reduced total Mg2+. Prophylactic MgSO4 prevented the post-traumatic decline in intracellular free Mg2+ and significantly improved acut…
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