THERAPY DOSSIER · th-a7aec415f65f

Magnesium sulfate (MgSO4)

Drug · ChEMBL records mechanism_of_action as 'Unknown' (no molecular target assigned; FDA label reference)

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: ChEMBL records mechanism_of_action as 'Unknown' (no molecular target assigned; FDA label reference)
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: 1981
Development stage: Not recorded
ChEMBL record: CHEMBL2021423 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Magnesium sulfate; Magnesium sulphate; MgSO4; Epsom salt (heptahydrate); Magnesium sulfate heptahydrate
Note: Not recorded

Clinical trials 7

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00116623 ↗PHASE4terminated

Magnesium Sulfate Versus Indomethacin for Preterm Labor

Labor, Premature

Enrolment not recorded · Results not recorded

NCT03067896 ↗PHASE3unknown

Dexmedetomidine Versus Magnesium Sulphate Added to Intrathecal Bupivacaine on Spinal Block and Neonatal Outcome in Caesarean Delivery

Cesarean Section

Enrolment: 78 · Results not recorded

NCT05671081 ↗PHASE3completed

Dexmedetomidine Versus Magnesium Sulfate in Bilateral Bi-level Erector Spinae Plane Block in Corrective Scoliosis Surgery

Anesthesia, Analgesia

Enrolment: 60 · Results not recorded

NCT04769440 ↗PHASE2completed

Effect of MgSO4 Infusion on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Surgery

Anesthesia

Enrolment: 40 · Results not recorded

NCT07248358 ↗PHASE1completed

Ketamine vs Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy

Laparoscopic Cholecystectomy Surgery · Postoperative Pain Management

Enrolment: 78 · Results not recorded

NCT07445451 ↗NAcompleted

Analgesic, Hemodynamic and Respiratory Effects of IV Magnesium Sulfate and Dexmedetomidine During Transurethral Bladder Tumor Resection

Bladder Tumors · Spinal Anesthesia · Postoperative Pain

Enrolment: 93 · Results not recorded

NCT02454322 ↗Phase not recordedcompleted

The Effect of Magnesium on Maternal Mood, Cognitive Function, and Birth Experience

Depression, Postpartum

Enrolment: 300 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 3335524 ↗1988Reported benefit

Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma.

RatTBIFluid percussionInbred strain not specifiedMaleProphylactic treatment before injury

Model: Fluid percussion traumatic brain injury at graded severities

Fluid percussion injury caused a rapid and profound fall in brain intracellular free Mg2+ that correlated with injury severity, accompanied at high injury levels by reduced total Mg2+. Prophylactic MgSO4 prevented the post-traumatic decline in intracellular free Mg2+ and significantly improved acut…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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