Topical Application of Fibroblast Growth Factor 10-PLGA Microsphere Accelerates Wound Healing via Inhibition of ER Stress.
MouseWoundICRMaleTopical to the wound; intraperitoneal for 4-phenylbutyrate and tunicamycin1.6 ug FGF10 (free or microsphere-loaded) in 20 uL applied…Applied at the time of wounding (day 0)
Model: Splinted full-thickness excisional cutaneous wound: two 6 mm punch wounds on the dorsum with silicone splints (16 mm external, 8 mm internal diameter)
Topical FGF10-PLGA microspheres gave the smallest wound area and highest closure rate of all groups, with greater granulation thickness, collagen deposition, CD31 positive vessel density and PCNA positivity and reduced endoplasmic reticulum stress markers, outperforming free FGF10.
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