THERAPY DOSSIER · th-cf0f1ef5f0bd

Fibroblast growth factor 10 loaded poly(lactic-co-glycolic acid) microspheres (FGF10-PLGA)

Biologic · FGF10 growth factor delivered from PLGA microspheres; recombinant protein construct.

Evidence & regulatory context

Mechanism: FGF10 growth factor delivered from PLGA microspheres; recombinant protein construct.
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33354279 ↗2020Reported benefit

Topical Application of Fibroblast Growth Factor 10-PLGA Microsphere Accelerates Wound Healing via Inhibition of ER Stress.

MouseWoundICRMaleTopical to the wound; intraperitoneal for 4-phenylbutyrate and tunicamycin1.6 ug FGF10 (free or microsphere-loaded) in 20 uL applied…Applied at the time of wounding (day 0)

Model: Splinted full-thickness excisional cutaneous wound: two 6 mm punch wounds on the dorsum with silicone splints (16 mm external, 8 mm internal diameter)

Topical FGF10-PLGA microspheres gave the smallest wound area and highest closure rate of all groups, with greater granulation thickness, collagen deposition, CD31 positive vessel density and PCNA positivity and reduced endoplasmic reticulum stress markers, outperforming free FGF10.

Extraction: extract · Supplied extraction confidence: 0.82. Machine-extracted fields require source verification.

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