Protective Effects of p53 Regulatory Agents Against High-LET Radiation-Induced Injury in Mice.
MouseRadiationICRFemalen = Carbon-beam TBI n = 12 per irradiation group; iron-beam TBI…IntraperitonealVanadate 20 mg/kg (2 mg/mL in normal saline); 5CHQ 60 mg/kg…Vanadate 30 min before irradiation; 5CHQ 30 to 60 min before irradiation (pre-t…
Model: High-LET heavy-ion irradiation at HIMAC: carbon beam 290 MeV/nucleon (about 14 keV/um) and iron beam 500 MeV/nucleon (about 189 keV/um), delivered as total-body irradiation (7.0 to 8.5 Gy) or abdominal irradiation (11 to 18 Gy)
Vanadate markedly improved 60-day survival after carbon-beam total-body irradiation (92% and 83% versus 8.3% and 0% for vehicle at 7.0 and 7.5 Gy) and after iron-beam total-body irradiation, but gave no protection against carbon-beam abdominal irradiation, whereas 5CHQ protected against carbon-beam…
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