Evidence & regulatory context
- Mechanism
- No ChEMBL entry returned for sodium orthovanadate; preclinical phosphatase-inhibitor tool compound combination.
- Target
- Not recorded
- Injury models
- Radiation
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseRadiationICRFemalen = Carbon-beam TBI n = 12 per irradiation group; iron-beam TBI…IntraperitonealVanadate 20 mg/kg (2 mg/mL in normal saline); 5CHQ 60 mg/kg…Vanadate 30 min before irradiation; 5CHQ 30 to 60 min before irradiation (pre-t…
Model: High-LET heavy-ion irradiation at HIMAC: carbon beam 290 MeV/nucleon (about 14 keV/um) and iron beam 500 MeV/nucleon (about 189 keV/um), delivered as total-body irradiation (7.0 to 8.5 Gy) or abdominal irradiation (11 to 18 Gy)
Vanadate markedly improved 60-day survival after carbon-beam total-body irradiation (92% and 83% versus 8.3% and 0% for vehicle at 7.0 and 7.5 Gy) and after iron-beam total-body irradiation, but gave no protection against carbon-beam abdominal irradiation, whereas 5CHQ protected against carbon-beam…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
MouseRadiationICR (Imprinting Control Region)Femalen = At least 30 mice per experimental group with experiments re…Intraperitoneal injection20 mg/kg or 40 mg/kg as a single dose; continuation regimen…After irradiation, tested from immediately to 240 min post-irradiation, with 15…
Model: Total body X-irradiation at 200 kVp and 20 mA with 0.5 mm aluminium plus 0.5 mm copper filter at about 0.70 Gy/min, using 7.5 Gy for the bone marrow failure model, 5.5 to 7.5 Gy for the dose reduction factor, 7.0 Gy for micronucleus assay, 8.0 Gy for bone marrow pathology and 5.0 Gy for Noxa expression
A single 20 mg/kg intraperitoneal dose 15 min after total body irradiation gave 40.0 per cent 30-day survival versus complete lethality with saline, with 54.5 per cent at 40 mg/kg and 56.7 per cent with the 4-day continuation regimen, a dose reduction factor of about 1.2, improved haemograms and re…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
