Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats.

Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats.

Model: Acute colitis induced with trinitrobenzene sulfonic acid (TNBS)

Rectal carbon monoxide-saturated saline reduced acute TNBS-induced colonic ulceration and accelerated ulcer healing without raising serum carbon monoxide, and inhibited the rise in thiobarbituric acid-reactive substances and myeloperoxidase activity, with enhanced epithelial migration via Rho-kinas…

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