THERAPY DOSSIER · th-ac35ae2df63e

Carbon monoxide-saturated saline (prepared by bubbling 50% carbon monoxide gas into saline)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin · Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL1231840 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Carbon monoxide; Carboneum oxygenisatum; Carbon oxide (CO)
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02425579 ↗PHASE1completed

Phase I Trial of Inhaled Carbon Monoxide for Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)

Acute Respiratory Distress Syndrome (ARDS)

Enrolment: 12 · Results not recorded

Preclinical evidence 2

2 studies reported at therapy level; 2 evidence entries itemised.

PMID 33340673 ↗2020Reported benefit

Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats.

RatChemical/toxinWistarMaleRectal (enema)After colitis induction

Model: Acute colitis induced with trinitrobenzene sulfonic acid (TNBS)

Rectal carbon monoxide-saturated saline reduced acute TNBS-induced colonic ulceration and accelerated ulcer healing without raising serum carbon monoxide, and inhibited the rise in thiobarbituric acid-reactive substances and myeloperoxidase activity, with enhanced epithelial migration via Rho-kinas…

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

PMID 27170088 ↗2016Reported benefit

Carbon monoxide promotes gastric wound healing in mice via the protein kinase C pathway.

MouseWoundC57BL/6maleoralCO-saturated saline prepared by bubbling 50% CO gas into sa…beginning on day 3 after gastric ulcer induction

Model: acetic acid-induced gastric ulcer

Oral administration of CO-saturated saline accelerated gastric ulcer healing by promoting re-epithelialisation, and CO enhanced murine gastric epithelial cell migration in vitro through activation of protein kinase C.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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