Salmon acyl-ghrelin increases food intake and reduces doxorubicin-induced myocardial apoptosis in rats, likely by anti-oxidative activity.
RatChemical/toxinn = Five groups; n per group not statedSubcutaneousGiven for 7 days before doxorubicin administration (pre-treatment)
Model: Doxorubicin-induced acute cardiotoxicity and acute heart failure; doxorubicin 20 mg/kg body weight by intraperitoneal injection after 7 days of pre-treatment
Salmon acyl-ghrelin showed binding affinity similar to rat acyl-ghrelin at GHS-R1a, increased food intake and reduced doxorubicin-induced myocardial apoptosis with antioxidant activity, whereas salmon unacylated-ghrelin did not.
Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.