THERAPY DOSSIER · th-6991cc8b29f6

Salmon acyl-ghrelin (with salmon unacylated-ghrelin and rat acyl-ghrelin comparators)

Hormone · No confident ChEMBL match for the salmon orthologue. ChEMBL contains human ghrelin/lenomorelin (CHEMBL500468, max_phase 3) only; recorded as unresolved rather than substituting a different species sequence.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: No confident ChEMBL match for the salmon orthologue. ChEMBL contains human ghrelin/lenomorelin (CHEMBL500468, max_phase 3) only; recorded as unresolved rather than substituting a different species sequence.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00681486 ↗PHASE3completed

Ghrelin to improve appetite, nutritional state, metabolic integrity and physical functioning in cancer patients with progressive weight loss

Cancer

Enrolment: 30 · Results not recorded

NCT01474785 ↗PHASE1completed

RYGB improves metabolism by interrupting the gastric adipose tissue axis (human ghrelin infusion)

Obesity

Enrolment: 49 · Results not recorded

NCT01209416 ↗NAcompleted

Effect of pharmacological antilipolysis on the metabolic effects of ghrelin

Metabolism · Insulin Resistance · Hypopituitarism

Enrolment: 8 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33340558 ↗2020Reported benefit

Salmon acyl-ghrelin increases food intake and reduces doxorubicin-induced myocardial apoptosis in rats, likely by anti-oxidative activity.

RatChemical/toxinn = Five groups; n per group not statedSubcutaneousGiven for 7 days before doxorubicin administration (pre-treatment)

Model: Doxorubicin-induced acute cardiotoxicity and acute heart failure; doxorubicin 20 mg/kg body weight by intraperitoneal injection after 7 days of pre-treatment

Salmon acyl-ghrelin showed binding affinity similar to rat acyl-ghrelin at GHS-R1a, increased food intake and reduced doxorubicin-induced myocardial apoptosis with antioxidant activity, whereas salmon unacylated-ghrelin did not.

Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.

Loading the evidence…