Early intervention with levetiracetam prevents the development of cortical hyperexcitability and spontaneous epileptiform activity in two models of neurotrauma in rats.
RatTBIControlled cortical impactSprague-DawleyMale and femalen = n = 15 rats levetiracetam and n = 15 rats saline for the in…Bath application in vitro; intraperitoneal in vivo500 uM bath-applied in vitro; 60 to 150 mg/kg in vivoIn vitro applied immediately or delayed by 30 to 80 min after injury; in vivo g…
Model: Two models: in vitro traumatised neocortical slices (400 to 450 um, surgical cut separating superficial from deeper layers) and in vivo non-penetrating focal controlled cortical impact to neocortex (5.0 mm diameter, 2.0 mm depth)
Levetiracetam applied within 60 min of injury reduced by more than 50% the proportion of slices showing stimulus-evoked epileptiform activity and raised the stimulus threshold 2 to 4 fold, and in vivo treatment reduced the proportion of animals with spontaneous and evoked epileptiform bursts, sugge…
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