Levetiracetam

Early intervention with levetiracetam prevents the development of cortical hyperexcitability and spontaneous epileptiform activity in two models of neurotrauma in rats.

Model: Two models: in vitro traumatised neocortical slices (400 to 450 um, surgical cut separating superficial from deeper layers) and in vivo non-penetrating focal controlled cortical impact to neocortex (5.0 mm diameter, 2.0 mm depth)

Levetiracetam applied within 60 min of injury reduced by more than 50% the proportion of slices showing stimulus-evoked epileptiform activity and raised the stimulus threshold 2 to 4 fold, and in vivo treatment reduced the proportion of animals with spontaneous and evoked epileptiform bursts, sugge…

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Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury.

Model: Severe penetrating ballistic-like brain injury with post-traumatic nonconvulsive seizures monitored by continuous electroencephalography for 72 hours

Levetiracetam 25 to 100 mg/kg and gabapentin 6.25 to 25 mg/kg each reduced seizure frequency and duration, but the combination gave no additional benefit and isobolographic analysis did not reach additivity.

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Research on the Effects of Levetiracetam in Spinal Cord Injury Model in Rats: An Experimental Study.

Model: T7-8 dorsal laminectomy with temporary vascular aneurysm clip compression of the spinal cord for 1 minute

Both levetiracetam and methylprednisolone improved histopathological architecture during the acute phase but this was not sustained in the subacute period, and neither agent altered biochemical measures at either stage.

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Dose-dependent effects of levetiracetam after hypoxia and hypothermia in the neonatal mouse brain.

Model: Acute systemic hypoxia (90 min at 6% oxygen) in neonatal mice, a model of perinatal asphyxia

Hypothermia produced acute and long-term neuroprotection by reducing apoptosis and preserving myelinating oligodendrocytes and neurons. Low-dose levetiracetam caused no adverse effects but added no neuroprotection, whereas high-dose levetiracetam alone or with hypothermia increased neuronal apoptos…

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Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage

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