Upregulation of Nucleotide-Binding Oligomerization Domain-, LRR- and Pyrin Domain-Containing Protein 3 in Motoneurons Following Peripheral Nerve Injury in Mice.

PMID 33328988 ↗2020Reported benefit

Upregulation of Nucleotide-Binding Oligomerization Domain-, LRR- and Pyrin Domain-Containing Protein 3 in Motoneurons Following Peripheral Nerve Injury in Mice.

MouseOtherBALB/c (non-transgenic)Malen = 33 mice in total: 30 for immunohistochemistry (10 non-opera…Intraperitoneal1 mg/kg body weight (0.25 mg/ml diazoxide in 10 mg/ml DMSO,…First dose 3 h after hypoglossal axotomy (post-operative treatment paradigm)

Model: Acute peripheral nerve injury: unilateral hypoglossal (cranial nerve XII) axotomy with removal of a 2 to 3 mm nerve segment, and target deprivation of the oculomotor nerve by unilateral eye enucleation; survival 4 days

Axotomy raised NLRP3 staining in the hypoglossal nucleus (27.25 +/- 4.87% vs 1.13 +/- 0.51%, p < 0.0005) and oculomotor nucleus (8.04 +/- 1.98% vs 2.66 +/- 0.34%, p < 0.05), with NLRP3 translocation to the cytoplasm in 82.24 +/- 5.38% of neurons on the injured side, and 1.873-fold and 1.893-fold ri…

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Upregulation of Nucleotide-Binding Oligomerization Domain-, LRR- and Pyrin Domain-Containing Protein 3 in Motoneurons Following Peripheral Nerve Injury in Mice.

Evidence by therapy association

Upregulation of Nucleotide-Binding Oligomerization Domain-, LRR- and Pyrin Domain-Containing Protein 3 in Motoneurons Following Peripheral Nerve Injury in Mice.