Diazoxide Choline Controlled-Release Tablet (DCCR) in Prader-Willi Syndrome
Prader-Willi Syndrome
Enrolment: 127 · Results not recorded
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Drug · KATP channel opener (OPENER) at KCNJ11 and KCNJ8; direct interaction, disease efficacy true
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Prader-Willi Syndrome
Enrolment: 127 · Results not recorded
Prader-Willi Syndrome
Enrolment: 115 · Results not recorded
Infant, Newborn, Diseases · Hypoglycemia · Infant, Large for Gestational Age
Enrolment: 100 · Results not recorded
Hypertriglyceridemia
Enrolment: 80 · Results not recorded
Hypothalamic Obesity
Enrolment: 9 · Results not recorded
Diabetes Mellitus, Type 2 · Glucose Metabolism Disorders
Enrolment: 0 · Results not recorded
Diabetes Mellitus · Glucose Metabolism Disorders
Enrolment: 100 · Results not recorded
Hypertriglyceridemia
Enrolment: 12 · Results not recorded
Hyperinsulinemia · Insulin Resistance · Non-Alcoholic Fatty Liver Disease · Prediabetic State · Obesity
Enrolment: 25 · Results not recorded
Glycogen Storage Disease Type I
Enrolment: 15 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Acute peripheral nerve injury: unilateral hypoglossal (cranial nerve XII) axotomy with removal of a 2 to 3 mm nerve segment, and target deprivation of the oculomotor nerve by unilateral eye enucleation; survival 4 days
Axotomy raised NLRP3 staining in the hypoglossal nucleus (27.25 +/- 4.87% vs 1.13 +/- 0.51%, p < 0.0005) and oculomotor nucleus (8.04 +/- 1.98% vs 2.66 +/- 0.34%, p < 0.05), with NLRP3 translocation to the cytoplasm in 82.24 +/- 5.38% of neurons on the injured side, and 1.873-fold and 1.893-fold ri…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Acute subdural haematoma produced by subdural infusion of 400 microlitres of autologous venous blood
Intraventricular diazoxide before acute subdural haematoma significantly reduced infarct volume and brain oedema, and this protection was abolished by co-treatment with 5-hydroxydecanoate, while 5-hydroxydecanoate alone increased infarct volume.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.