Protective effects of Gamma Oryzanol on distant organs after kidney ischemia-reperfusion in rats: A focus on liver protection.
RatIschaemia-reperfusionRenalWistarMalen = 24 Wistar rats in total, 12 of which received gamma oryzanolOral gavage and intraperitoneal injection (both used)100 mg/kg, single dose1 h before induction of ischaemia-reperfusion (pre-treatment)
Model: Renal ischaemia-reperfusion injury producing acute kidney injury, with assessment of distant organ (brain, heart and liver) damage
Gamma oryzanol pre-treatment significantly restored antioxidant protein levels and activity in brain, heart and liver (p < 0.05), lowered hepatic IL-1, IL-6 and TNF-alpha (p < 0.01), reduced the Bax/Bcl-2 ratio and caspase-3 expression to diminish hepatic apoptosis (p < 0.01), and attenuated the de…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.