THERAPY DOSSIER · th-3fbe79589290

Gamma oryzanol (GO), extracted from rice bran oil

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL4297798 ↗
ChEMBL max phase: 0.5 / 4 (development scale, not regulatory approval)
Synonyms: gamma-oryzanol; Gamma oryzanol; Oryzanol
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02944084 ↗EARLY_PHASE1completed

Absorption and Excretion Kinetics of the Bioactive Ingredients of Rice Bran Extract

Safety After Oral Intake · Pharmacokinetics After Oral Intake

Enrolment: 12 · Results not recorded

NCT05922800 ↗NAunknown

Effectiveness and Safety of Electro-press Needle and Gamma-oryzanol for Menopause-associated Hot Flashes: Protocol of a Randomized Controlled Trial

Hot Flashes · Acupuncture Therapy · Perimenopausal Disorder · Postmenopausal Symptoms

Enrolment: 64 · Results not recorded

NCT05271045 ↗NAunknown

Formulation of Canola Oil With Vitamins A and D and gamma-oryzanol and Evaluation of the Efficacy of Its Consumption Compared to Canola and Sunflower Oil Without gamma-oryzanol in Adults With Type 2 Diabetes: a Randomized Controlled Clinical Trial

Diabetes

Enrolment: 90 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33325270 ↗2020Reported benefit

Protective effects of Gamma Oryzanol on distant organs after kidney ischemia-reperfusion in rats: A focus on liver protection.

RatIschaemia-reperfusionRenalWistarMalen = 24 Wistar rats in total, 12 of which received gamma oryzanolOral gavage and intraperitoneal injection (both used)100 mg/kg, single dose1 h before induction of ischaemia-reperfusion (pre-treatment)

Model: Renal ischaemia-reperfusion injury producing acute kidney injury, with assessment of distant organ (brain, heart and liver) damage

Gamma oryzanol pre-treatment significantly restored antioxidant protein levels and activity in brain, heart and liver (p < 0.05), lowered hepatic IL-1, IL-6 and TNF-alpha (p < 0.01), reduced the Bax/Bcl-2 ratio and caspase-3 expression to diminish hepatic apoptosis (p < 0.01), and attenuated the de…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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