Phytochemical Profile, Safety Assessment and Wound Healing Activity of Artemisia absinthium L.
MixedWoundWistar albino rats (wound healing and acute dermal irritation); Swiss albino mice (acute oral toxicity)Female for the acute oral toxicity mice (nulliparous, non-pregnant); sex of the rats not statedn = Wound healing: 7 groups of 5 rats (35 rats). Acute dermal i…Topical (cutaneous) for wound healing and dermal irritation; oral gavage for acute oral toxicity500 mg of ointment per rat per topical application (5% or 1…Topical treatment started on the day of wounding, immediately after excision an…
Model: Full-thickness excisional skin wound: a 2.5 cm diameter circular wound excised from the shaved lumbar dorsal region under ketamine (90 mg/kg) and xylazine (10 mg/kg) intraperitoneal anaesthesia
MEO 5% and MEO 10% significantly improved wound contraction versus untreated animals (p < 0.001), with MEO 10% reaching 81.49 +/- 2.83% contraction compared with 84.52 +/- 0.80% for the reference drug Cicatryl-Bio and no significant difference between them. Histology showed greater collagen deposit…
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