THERAPY DOSSIER · th-b6eff4981a6b

Methanol extract of Artemisia absinthium L. flowering aerial parts incorporated into petroleum jelly ointment at 5% and 10% (MEO 5% and MEO 10%)

Nutraceutical · Methanolic wormwood (Artemisia absinthium) aerial-part extract in ointment; multi-component botanical.

Evidence & regulatory context

Mechanism: Methanolic wormwood (Artemisia absinthium) aerial-part extract in ointment; multi-component botanical.
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33321822 ↗2020Reported benefit

Phytochemical Profile, Safety Assessment and Wound Healing Activity of Artemisia absinthium L.

MixedWoundWistar albino rats (wound healing and acute dermal irritation); Swiss albino mice (acute oral toxicity)Female for the acute oral toxicity mice (nulliparous, non-pregnant); sex of the rats not statedn = Wound healing: 7 groups of 5 rats (35 rats). Acute dermal i…Topical (cutaneous) for wound healing and dermal irritation; oral gavage for acute oral toxicity500 mg of ointment per rat per topical application (5% or 1…Topical treatment started on the day of wounding, immediately after excision an…

Model: Full-thickness excisional skin wound: a 2.5 cm diameter circular wound excised from the shaved lumbar dorsal region under ketamine (90 mg/kg) and xylazine (10 mg/kg) intraperitoneal anaesthesia

MEO 5% and MEO 10% significantly improved wound contraction versus untreated animals (p < 0.001), with MEO 10% reaching 81.49 +/- 2.83% contraction compared with 84.52 +/- 0.80% for the reference drug Cicatryl-Bio and no significant difference between them. Histology showed greater collagen deposit…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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