Protective Effect of Polydeoxyribonucleotide Against CCl4-Induced Acute Liver Injury in Mice.
MouseChemical/toxinICRmalen = n = 8 per group in 5 groups (40 mice)intraperitoneal injection2, 4 or 8 mg/kg PDRN dissolved in 200 microlitres of distil…Started 1 day after the first CCl4 injection
Model: Carbon tetrachloride induced acute liver injury, with 10 mL/kg CCl4 (0.4 mL CCl4 solubilised in 100 mL corn oil) given intraperitoneally 4 times, once every 2 days
CCl4 raised serum AST and ALT, increased hepatic TNF-alpha, IL-1 beta and IL-6, suppressed adenosine A2A receptor, increased the Bax to Bcl-2 ratio and increased TUNEL positive hepatocytes (all P < 0.05). PDRN reduced serum AST and ALT, suppressed TNF-alpha (all doses), IL-1 beta (8 mg/kg only) and…
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