Healing of Periodontal Supra-bony Defects Treated With Hyaluronic Acid and Polydeoxyribonucleotides
Periodontal Diseases · Wound Healing
Enrolment: 24 · Results not recorded
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Drug · No ChEMBL entry (polymeric DNA-derived mixture, not a defined small molecule); literature mechanism is adenosine A2A receptor agonism plus salvage-pathway nucleotide supply. Marketed as Placentex (Mastelli).
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Periodontal Diseases · Wound Healing
Enrolment: 24 · Results not recorded
Rotator Cuff Tear
Enrolment: 79 · Results not recorded
Lateral Epicondylitis
Enrolment: 40 · Results not recorded
Scleroderma Disease
Enrolment: 25 · Results not recorded
Facial Scarring
Enrolment: 36 · Results not recorded
Genitourinary Syndrome of Menopause · Vaginal Atrophy
Enrolment: 136 · Results not recorded
Atrophic Acne Scars
Enrolment: 20 · Results not recorded
Skin Wrinkling
Enrolment: 25 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Carbon tetrachloride induced acute liver injury, with 10 mL/kg CCl4 (0.4 mL CCl4 solubilised in 100 mL corn oil) given intraperitoneally 4 times, once every 2 days
CCl4 raised serum AST and ALT, increased hepatic TNF-alpha, IL-1 beta and IL-6, suppressed adenosine A2A receptor, increased the Bax to Bcl-2 ratio and increased TUNEL positive hepatocytes (all P < 0.05). PDRN reduced serum AST and ALT, suppressed TNF-alpha (all doses), IL-1 beta (8 mg/kg only) and…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.