Ursolic acid alleviates heat stress-induced lung injury by regulating endoplasmic reticulum stress signaling in mice.
MouseOtherInstitute of Cancer Research (ICR)MaleOral administration40 mg/kg body weight per dayPretreatment, given for 2 days before heat stress exposure
Model: Heat stress-induced acute lung injury: mice housed at normal temperature (23 plus or minus 1 degrees C) then exposed to high temperature (41 plus or minus 1 degrees C) for 2 h
Heat stress increased apoptosis, hydrogen peroxide production, serum TNF-alpha, IL-6 and IL-1beta, and lung malondialdehyde, lactate dehydrogenase and myeloperoxidase activity, while reducing superoxide dismutase and catalase activity. All these changes were significantly prevented by ursolic acid…
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