Nutraceutical
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Spinal Cord Injuries · Tetraplegia · Paraplegia · Muscle Loss · Atrophy, Muscular · Insulin Resistance
Enrolment: 10 · Results not recorded
Sarcopenia
Enrolment: 54 · Results not recorded
Metabolic Syndrome X
Enrolment: 24 · Results not recorded
Primary Sclerosing Cholangitis
Enrolment: 0 · Results not recorded
Prostate Cancer
Enrolment: 0 · Results not recorded
Bioavailability of Phytonutrients
Enrolment: 18 · Results not recorded
Sarcopenia
Enrolment: 105 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Heat stress-induced acute lung injury: mice housed at normal temperature (23 plus or minus 1 degrees C) then exposed to high temperature (41 plus or minus 1 degrees C) for 2 h
Heat stress increased apoptosis, hydrogen peroxide production, serum TNF-alpha, IL-6 and IL-1beta, and lung malondialdehyde, lactate dehydrogenase and myeloperoxidase activity, while reducing superoxide dismutase and catalase activity. All these changes were significantly prevented by ursolic acid…
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
Model: Spinal cord injury in mouse; specific injury method not stated in the abstract
Oral ursolic acid started 1 hour after injury and continued daily for 6 weeks improved regaining of motor function and axonal regrowth, decreased astrogliosis, lowered proinflammatory IL-6 and TNF-alpha in the acute phase, and activated MAPK and PI3K/Akt/mTOR signalling in the injured spinal cord.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Acute whole-body irradiation with 5 Gy, or fractionated exposure with 0.5 Gy daily for 10 days to a total dose of 5 Gy
Acute 5 Gy irradiation caused deficits in contextual learning and memory and in novel object recognition and impaired subgranular zone neurogenesis, while fractionated exposure caused less loss of newly generated neurons and no behavioural deficit. Ursolic acid at 25 mg/kg daily for 30 days greatly…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
