A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis.
RatCrushOther / unspecifiedWistarMalen = 6 rats per group (vehicle and KUS121); 4 biological replica…Intra-articular injection into the right knee joint along the patellar tendon using a 27 G syringe100 microlitres of KUS121 at 20 mg/mL dissolved in 5% gluco…Immediately before cyclic compressive loading and on days 1, 3, 5, 7, 14 and 21…
Model: Post-traumatic osteoarthritis induced by cyclic compressive loading of the right knee (pre-load 5 N, peak load 20 N, approach speed 1 mm/s, 10 s rest interval, 60 cycles over approximately 20 min)
Intra-articular KUS121 significantly lowered modified Mankin scores at 2 and 4 weeks, reduced damaged cartilage lesion volume, increased the number of live chondrocytes, increased Safranin O staining intensity and lowered synovitis scores at 4 weeks. KUS121 significantly reduced TUNEL-, CHOP-, MMP-…
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