Phase 2 Study of Intravitreal KUS121 in Non-Arteritic Central Retinal Artery Occlusion
Central Retinal Artery Occlusion
Enrolment: 17 · Results not recorded
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Drug · VCP (valosin-containing protein) ATPase-modulating small molecule; not returned by ChEMBL name search.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Central Retinal Artery Occlusion
Enrolment: 17 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Post-traumatic osteoarthritis induced by cyclic compressive loading of the right knee (pre-load 5 N, peak load 20 N, approach speed 1 mm/s, 10 s rest interval, 60 cycles over approximately 20 min)
Intra-articular KUS121 significantly lowered modified Mankin scores at 2 and 4 weeks, reduced damaged cartilage lesion volume, increased the number of live chondrocytes, increased Safranin O staining intensity and lowered synovitis scores at 4 weeks. KUS121 significantly reduced TUNEL-, CHOP-, MMP-…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.