Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study.
RatTBIControlled cortical impactSprague DawleyMalen = n = 22 rats in total; 6 per 24 h group (TBI control, TBI xe…Inhalation in spontaneously breathing animals via a closed-circuit chamber system50% xenon with 25% oxygen, balance nitrogen (supplied as 49…Treatment started 30 min after controlled cortical impact
Model: Severe controlled cortical impact (CCI) over the right parietal cortex; flat 4 mm tip, impact velocity 6 m/s, impact duration 400 ms, penetration depth 3.0 mm, under isoflurane anaesthesia with buprenorphine analgesia
Primary lesion volume of 49 (7) mm3 at 15 min increased 2.7-fold to 134 (23) mm3 at 24 h. Xenon reduced secondary injury volume by 34%, although this did not reach statistical significance. TBI controls showed significant reductions in locomotor speed and stride length at 24 h that were absent in x…
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