Protection of Xenon Against Postoperative Oxygen Impairment in Adults Undergoing Stanford Type-A Acute Aortic Dissection Surgery
Acute Lung Injury
Enrolment: 160 · Results not recorded
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Drug · ChEMBL records list diagnostic-agent and MRI contrast-agent mechanisms for xenon isotopes; ATC N01AX15 classifies xenon as a general anaesthetic.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute Lung Injury
Enrolment: 160 · Results not recorded
Panic Disorder
Enrolment: 200 · Results not recorded
Pulmonary Embolism
Enrolment: 18 · Results not recorded
Idiopathic Pulmonary Fibrosis · Hypersensitivity Pneumonitis
Enrolment: 0 · Results not recorded
Respiratory Disorders
Enrolment: 300 · Results not recorded
Hypoxic Ischaemic Encephalopathy
Enrolment: 32 · Results not recorded
Major Depressive Disorder · Bipolar Depression
Enrolment: 20 · Results not recorded
Cystic Fibrosis
Enrolment: 20 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Oxygen-glucose deprivation in organotypic hippocampal brain slices in vitro
Xenon and argon at 0.5 atm each reduced injury by 96 per cent and were not significantly different from uninjured sham slices, whereas helium, neon and krypton had no protective effect. Elevated glycine reversed the protection by xenon but not argon.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Severe controlled cortical impact (CCI) over the right parietal cortex; flat 4 mm tip, impact velocity 6 m/s, impact duration 400 ms, penetration depth 3.0 mm, under isoflurane anaesthesia with buprenorphine analgesia
Primary lesion volume of 49 (7) mm3 at 15 min increased 2.7-fold to 134 (23) mm3 at 24 h. Xenon reduced secondary injury volume by 34%, although this did not reach statistical significance. TBI controls showed significant reductions in locomotor speed and stride length at 24 h that were absent in x…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Rat renal transplantation model in which the Lewis renal graft was stored in 4 degrees C Soltran preserving solution for 24 h before transplantation into a Lewis recipient, causing remote lung injury; parallel in vitro studies used A549 human lung epithelial cells challenged with H2O2, TNF-alpha or conditioned medium from hypothermia-hypoxia insulted HK-2 cells
Recipients of ischaemic renal grafts developed pulmonary injury. Xenon enhanced HIF-1alpha, attenuating HMGB-1 translocation and NF-kappaB activation in A549 cells, and enhanced phospho-mTOR, HIF-1alpha and Bcl-2 with increased lung cell proliferation. After grafting, HMGB-1 translocation and TLR-4…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.