Ulinastatin alleviates cerebral ischemia-reperfusion injury in rats by activating the Nrf-2/HO-1 signaling pathway.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague DawleyMalen = 8 rats per group across 7 groups (56 rats surviving to 24 h)Intraperitoneal injection300,000 U/kg15 min after MCAO
Model: Cerebral ischaemia-reperfusion induced by intraluminal middle cerebral artery occlusion (MCAO) with a 0.3 mm nylon thread inserted 18.0 plus or minus 2.0 mm, 2 h of ischaemia followed by 24 h of reperfusion, under sodium pentobarbital anaesthesia (30 mg/kg intraperitoneally)
Ulinastatin ameliorated MCAO-induced histological damage, reduced TUNEL-positive apoptotic cells and infarct volume, and lowered caspase-3 and ICAM-1 expression (P<0.01). It raised SOD activity and GSH content and lowered MDA and ROS, and reduced serum IL-6, IL-1beta and IL-18 (P<0.01). Nrf-2 and H…
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