Study of Ulinastatin in Inhalation Lung Injury
Inhalation Injury
Enrolment: 120 · Results not recorded
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Biologic
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Inhalation Injury
Enrolment: 120 · Results not recorded
Acute Kidney Injury
Enrolment: 500 · Results not recorded
Severe Sepsis · Septic Shock · MODS
Enrolment: 175 · Results not recorded
Congenital Heart Diseases
Enrolment: 450 · Results not recorded
Oral Mucositis (Ulcerative) Due to Radiation
Enrolment: 179 · Results not recorded
Ventilator-associated Bacterial Pneumonia · Mechanical Ventilation Complication
Enrolment: 60 · Results not recorded
Acute Respiratory Distress Syndrome
Enrolment: 60 · Results not recorded
COVID-19
Enrolment: 0 · Results not recorded
Acute Aortic Dissection
Enrolment: 220 · Results not recorded
Aortic Aneurysm and Dissection
Enrolment: 300 · Results not recorded
Cardiac Surgery
Enrolment: 90 · Results not recorded
Acute Respiratory Distress Syndrome · Critical Illness
Enrolment: 840 · Results not recorded
Aortic Dissection · Aortic Dissection Aneurysm
Enrolment: 200 · Results not recorded
Sepsis-Associated Encephalopathy
Enrolment: 2734 · Results not recorded
Sepsis
Enrolment: 567 · Results not recorded
ECMO · Inflammatory Response
Enrolment: 144 · Results not recorded
8 studies reported at therapy level; 8 evidence entries itemised.
Model: Moderate pulmonary contusion from blunt chest trauma causing acute lung injury
High-dose urinary trypsin inhibitor significantly reduced bronchoalveolar lavage neutrophil count and TNF-alpha and lung malondialdehyde, and raised superoxide dismutase and catalase activity (P less than 0.05), with a dose-dependent trend. Bronchoalveolar albumin fell without significance, and the…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: 30% TBSA full-thickness burn with delayed resuscitation; acute lung injury
Ulinastatin reduced inflammatory mediators and microvascular permeability and improved pulmonary function in burn-induced acute lung injury.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Cerebral ischaemia-reperfusion induced by intraluminal middle cerebral artery occlusion (MCAO) with a 0.3 mm nylon thread inserted 18.0 plus or minus 2.0 mm, 2 h of ischaemia followed by 24 h of reperfusion, under sodium pentobarbital anaesthesia (30 mg/kg intraperitoneally)
Ulinastatin ameliorated MCAO-induced histological damage, reduced TUNEL-positive apoptotic cells and infarct volume, and lowered caspase-3 and ICAM-1 expression (P<0.01). It raised SOD activity and GSH content and lowered MDA and ROS, and reduced serum IL-6, IL-1beta and IL-18 (P<0.01). Nrf-2 and H…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Crush syndrome-induced acute kidney injury produced with a digital crush injury device platform
Ulinastatin lowered serum blood urea nitrogen, creatine kinase, creatinine, myoglobin and potassium compared with the untreated crush syndrome group, reduced inflammatory cell infiltration and myoglobin casts, increased the proportion of CD4 positive CD25 positive Foxp3 positive regulatory T cells…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute lung injury induced by intratracheal instillation of lipopolysaccharide 5 mg/kg
Ulinastatin attenuated lipopolysaccharide-induced lung injury, improving histological changes and reducing the lung wet/dry ratio, myeloperoxidase activity and Evans blue extravasation. Bronchoalveolar lavage pro-inflammatory cytokines and cell counts were reduced, and MAPK and NF-kappaB activation…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Heat stress model with mice held at 35.5 +/- 0.5 degrees C and 60 +/- 5% humidity until core temperature reached 40 or 42 degrees C, followed in some groups by 6 h cooling at 25 +/- 0.5 degrees C; sham controls held at 25 degrees C
Heat stress caused progressive intestinal injury with rising Chiu scores and increased serum and intestinal diamine oxidase, D-lactic acid and cryptdin-2, worsening further after 6 h of cooling in animals reaching 42 degrees C. Ulinastatin 100,000 U/kg given immediately after the core temperature r…
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Model: Remote lung injury from lower limb ischaemia-reperfusion, rubber band ligation of the lower limbs for 3 hours followed by 3 hours of reperfusion
Lower limb ischaemia-reperfusion caused marked pulmonary inflammatory cell infiltration, haemorrhage and oedema, a fall in oxygenation index, increased lavage white cell count and raised lavage TNF-alpha, IL-1 and IL-6, with increased phosphorylated ERK, JNK and p38. Intravenous ulinastatin pre-tre…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Smoke inhalation acute lung injury
Ulinastatin attenuated lung histopathological change, improved pulmonary function, inhibited neutrophil accumulation, reduced pulmonary oedema and inflammatory response, prevented activation of NF-kappaB and p-JNK, and mitigated subsequent pulmonary fibrosis as shown by hydroxyproline content and c…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.