Intravitreal injection worsens outcomes in a mouse model of indirect traumatic optic neuropathy from closed globe injury.
MouseTBIBlast / overpressureC57Bl/6JIntravitreal1 microlitre single intravitreal injection via 30 gauge Ham…One day after the last blast exposure
Model: Air-blast induced indirect traumatic optic neuropathy from closed globe injury, two 15 psi blasts 0.5 s apart to the left eye daily for three days
A single intravitreal saline injection given one day after closed globe trauma reduced electroretinogram a-wave and b-wave amplitudes, lowered total optic nerve axon counts even in uninjured animals and increased degenerating axon profiles in injured animals. Retinal and optic nerve IL-1alpha and I…
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