THERAPY DOSSIER · th-a77dbc8753f4

Intravitreal injection of normal saline (buffer)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33238184 ↗2020Reported harm

Intravitreal injection worsens outcomes in a mouse model of indirect traumatic optic neuropathy from closed globe injury.

MouseTBIBlast / overpressureC57Bl/6JIntravitreal1 microlitre single intravitreal injection via 30 gauge Ham…One day after the last blast exposure

Model: Air-blast induced indirect traumatic optic neuropathy from closed globe injury, two 15 psi blasts 0.5 s apart to the left eye daily for three days

A single intravitreal saline injection given one day after closed globe trauma reduced electroretinogram a-wave and b-wave amplitudes, lowered total optic nerve axon counts even in uninjured animals and increased degenerating axon profiles in injured animals. Retinal and optic nerve IL-1alpha and I…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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